The urinary microbiota composition and functionality of calcium oxalate stone formers.

ABSTRACT:

Background

Accumulated evidences indicate that dysbiosis of the urinary microbiota is associated with kidney stone formation. In the present study, we aimed to investigate the urinary microbiota composition and functionality of patients with calcium oxalate stones and compare it with those of healthy individuals.

Method

We collected bladder urine samples from 68 adult patients with calcium oxalate stones and 54 age-matched healthy controls by transurethral catheterization. 16S rRNA gene and shotgun sequencing were utilized to characterize the urinary microbiota and functionality associated with calcium oxalate stones.

Results

After further exclusion, a total of 100 subjects was finally included and analyzed. The diversity of the urinary microbiota in calcium oxalate s

SUBMITTER: Xie J 

PROVIDER: S-EPMC11190077 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature