Re-emergence of T lymphocyte-mediated synaptopathy in progressive multiple sclerosis.

ABSTRACT:

Background

Secondary progressive multiple sclerosis (SPMS) is defined by the irreversible accumulation of disability following a relapsing-remitting MS (RRMS) course. Despite treatments advances, a reliable tool able to capture the transition from RRMS to SPMS is lacking. A T cell chimeric MS model demonstrated that T cells derived from relapsing patients exacerbate excitatory transmission of central neurons, a synaptotoxic event absent during remitting stages. We hypothesized the re-emergence of T cell synaptotoxicity during SPMS and investigated the synaptoprotective effects of siponimod, a sphingosine 1-phosphate receptor (S1PR) modulator, known to reduce grey matter damage in SPMS patients.

Methods

Data from healthy controls (HC), SPMS patients, and siponimod-treated SPM

SUBMITTER: Sanna K 

PROVIDER: S-EPMC11190089 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature