ROS are required for the germinative cell proliferation and metacestode larval growth of Echinococcus multilocularis.

ABSTRACT: The potentially lethal zoonotic disease alveolar echinococcosis (AE) is caused by the metacestode larval stages of the tapeworm Echinococcus multilocularis. Metacestode growth and proliferation occurs within the inner organs of mammalian hosts, which is associated with complex molecular parasite-host interactions. The host has developed various ways to resist a parasitic infection, and the production of reactive oxygen species (ROS) is one of the most important strategies. Here, we found that scavenging of ROS reduced metacestode larval growth and germinative cell proliferation in in vivo models. Furthermore, using in vitro-cultured metacestode vesicles, we found that increased ROS levels enhanced metacestode growth and germinative cell proliferation, which was achieve

SUBMITTER: Tian Y 

PROVIDER: S-EPMC11190091 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature