The roles of IRF8 in nonspecific orbital inflammation: an integrated analysis by bioinformatics and machine learning.

ABSTRACT:

Background

Nonspecific Orbital Inflammation (NSOI) represents a persistent and idiopathic proliferative inflammatory disorder, characterized by polymorphous lymphoid infiltration within the orbit. The transcription factor Interferon Regulatory Factor 8 (IRF8), integral to the IRF protein family, was initially identified as a pivotal element for the commitment and differentiation of myeloid cell lineage. Serving as a central regulator of innate immune receptor signaling, IRF8 orchestrates a myriad of functions in hematopoietic cell development. However, the intricate mechanisms underlying IRF8 production remain to be elucidated, and its potential role as a biomarker for NSOI is yet to be resolved.

Methods

IRF8 was extracted from the intersection analysis of common DEGs of GSE

SUBMITTER: Wu Z 

PROVIDER: S-EPMC11190126 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature