Predicting human and viral protein variants affecting COVID-19 susceptibility and repurposing therapeutics.

ABSTRACT: The COVID-19 disease is an ongoing global health concern. Although vaccination provides some protection, people are still susceptible to re-infection. Ostensibly, certain populations or clinical groups may be more vulnerable. Factors causing these differences are unclear and whilst socioeconomic and cultural differences are likely to be important, human genetic factors could influence susceptibility. Experimental studies indicate SARS-CoV-2 uses innate immune suppression as a strategy to speed-up entry and replication into the host cell. Therefore, it is necessary to understand the impact of variants in immunity-associated human proteins on susceptibility to COVID-19. In this work, we analysed missense coding variants in several SARS-CoV-2 proteins and their human protein interactors that

SUBMITTER: Waman VP 

PROVIDER: S-EPMC11190248 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature