Causal association between blood metabolites and risk of hypertension: a Mendelian randomization study.

ABSTRACT:

Background

Previous studies have indicated a strong link between blood metabolites and hypertension, however the causality of metabolites and hypertension is unknown.

Methods

Two-sample Mendelian randomization (MR) analysis was performed to assess the causal relationship between 486 blood metabolites and essential hypertension (EHT). Blood metabolite GWAS data was utilized as the exposure, with EHT GWAS data as the outcome. To further verify the results, another different source of EHT GWAS data was repeatedly analyzed. The major MR analytic approach used to determine causality was inverse variance weighted (IVW), with MR-Egger, Weighted Median, and MR-PRESSO models serving as supplements. We used the Cochran Q test to examine heterogeneity. Horizontal pleiotropy was examine

SUBMITTER: Cheng T 

PROVIDER: S-EPMC11190327 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature