Smad4 is essential for epiblast scaling and morphogenesis after implantation, but nonessential before implantation.

ABSTRACT: Bone morphogenic protein (BMP) signaling plays an essential and highly conserved role in embryo axial patterning in animal species. However, in mammalian embryos, which develop inside the mother, early development includes a preimplantation stage, which does not occur in externally developing embryos. During preimplantation, the epiblast is segregated from extra-embryonic lineages that enable implantation and development in utero. Yet, the requirement for BMP signaling is imprecisely defined in mouse early embryos. Here, we show that, in contrast to previous reports, BMP signaling (SMAD1/5/9 phosphorylation) is not detectable until implantation when it is detected in the primitive endoderm - an extra-embryonic lineage. Moreover, preimplantation development appears to be normal following de

SUBMITTER: Kruger RE 

PROVIDER: S-EPMC11190579 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature