Reduced nicotine in cigarettes in a marketplace with alternative nicotine systems: randomized clinical trial.

ABSTRACT:

Background

Reducing cigarette addictiveness has the potential to avert millions of yearly tobacco-related deaths worldwide. Substantially reducing nicotine in cigarettes decreases cigarette consumption, but no large clinical trial has determined the effects of reduced-nicotine cigarettes when other nicotine-containing products are available. The aim of this study was to examine the effects of reduced-nicotine cigarettes in the context of the availability of alternative nicotine delivery systems.

Methods

In a U.S. six-site, open-label, parallel-arm study, smokers were randomized for twelve weeks to an experimental marketplace containing cigarettes with either 0.4 mg or 15.8 mg nicotine per gram of tobacco; all had access to non-combusted alternative nicotine delivery systems

SUBMITTER: Hatsukami DK 

PROVIDER: S-EPMC11190722 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature