A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome.

ABSTRACT:

Importance

Sudden death and cardiac arrest frequently occur without explanation, even after a thorough clinical evaluation. Calcium release deficiency syndrome (CRDS), a life-threatening genetic arrhythmia syndrome, is undetectable with standard testing and leads to unexplained cardiac arrest.

Objective

To explore the cardiac repolarization response on an electrocardiogram after brief tachycardia and a pause as a clinical diagnostic test for CRDS.

Design, setting, and participants

An international, multicenter, case-control study including individual cases of CRDS, 3 patient control groups (individuals with suspected supraventricular tachycardia; survivors of unexplained cardiac arrest [UCA]; and individuals with genotype-positive catecholaminergic polymorphic ventric

SUBMITTER: Ni M 

PROVIDER: S-EPMC11190834 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature