Genome-wide association study identifies high-impact susceptibility loci for HCC in North America.

ABSTRACT:

Background and aims

Despite the substantial impact of environmental factors, individuals with a family history of liver cancer have an increased risk for HCC. However, genetic factors have not been studied systematically by genome-wide approaches in large numbers of individuals from European descent populations (EDP).

Approach and results

We conducted a 2-stage genome-wide association study (GWAS) on HCC not affected by HBV infections. A total of 1872 HCC cases and 2907 controls were included in the discovery stage, and 1200 HCC cases and 1832 controls in the validation. We analyzed the discovery and validation samples separately and then conducted a meta-analysis. All analyses were conducted in the presence and absence of HCV. The liability-scale heritability was 24.4% for

SUBMITTER: Hassan MM 

PROVIDER: S-EPMC11191046 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature