Impending HCC diagnosis in patients with cirrhosis after HCV cure features a natural killer cell signature.

ABSTRACT:

Background and aims

The risk of developing HCC in chronically infected patients with AQ2 HCV with liver cirrhosis is significantly elevated. This risk remains high even after a sustained virological response with direct-acting antivirals. To date, disease-associated signatures of NK cells indicating HCC development are unclear.

Approach and results

This study investigated NK cell signatures and functions in 8 cohorts covering the time span of HCC development, diagnosis, and onset. In-depth analysis of NK cell profiles from patients with cirrhosis who developed HCC (HCV-HCC) after sustained virological response compared with those who remained tumor-free (HCV-noHCC) revealed increasingly dissimilar NK cell signatures over time. We identified expression patterns with persisten

SUBMITTER: Engelskircher SA 

PROVIDER: S-EPMC11191062 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature