Transcriptome Study of rd1Mouse Brain and Association with Parkinson's Disease.

ABSTRACT: Degeneration of the retina is intrinsically associated with the pathogenesis and progression of neurodegenerative diseases. However, the cellular and molecular mechanisms underlying the association between neurodegeneration and retinal degeneration are still under exploration due to the complexity of the connectivity network of the nervous system. In this study, RNA-seq data from the brains of model retinitis pigmentosa (RP) mice and previously studied Parkinson's disease (PD) mice were analyzed to explore the commonalities between retinal degenerative and neurodegenerative diseases. Differentially expressed genes in RP were compared with neurodegenerative disease-related genes and intersecting genes were identified, including Cnr1 and Septin14. These genes were verified by quantitative re

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC11191077 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature