A Novel Poly(cytosine)-Based Electrochemical Biosensor for Sensitive and Selective Determination of Guanine in Biological Samples.

ABSTRACT: The novel poly(cytosine)-modified glassy carbon electrode-based electrochemical sensor was fabricated potentiodynamically for the detection of Guanine (G) in clinical and biological samples. The surface of the electrode was successfully activated by electropolymerization, and about a 7.5-fold current improvement due to modification was achieved. From the analysis of the dependence of peak current and peak potential on a scan rate, a higher R ² for the peak current on the square root of scan rate (R ² = 0.999) than the dependence of peak current on scan rate (R ² = 0.982) indicated that the oxidation of G at poly(cytosine)/GCE was predominantly diffusion controlled. The oxidative peak response of the electrode revealed a high linear rang

SUBMITTER: Metto M 

PROVIDER: S-EPMC11191103 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature