Novel hypoxia- and lactate metabolism-related molecular subtyping and prognostic signature for colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is a serious global health burden because of its high morbidity and mortality rates. Hypoxia and massive lactate production are hallmarks of the CRC microenvironment. However, the effects of hypoxia and lactate metabolism on CRC have not been fully elucidated. This study aimed to develop a novel molecular subtyping based on hypoxia-related genes (HRGs) and lactate metabolism-related genes (LMRGs) and construct a signature to predict the prognosis of patients with CRC and treatment efficacy.

Methods

Bulk and single-cell RNA-sequencing and clinical data of CRC were downloaded from the TCGA and GEO databases. HRGs and LMRGs were obtained from the Molecular Signatures Database. The R software package DESeq2 was used to perform differential expr

SUBMITTER: Huang A 

PROVIDER: S-EPMC11191174 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature