Short-term response of primary human meniscus cells to simulated microgravity.

ABSTRACT:

Background

Mechanical unloading of the knee articular cartilage results in cartilage matrix atrophy, signifying the osteoarthritic-inductive potential of mechanical unloading. In contrast, mechanical loading stimulates cartilage matrix production. However, little is known about the response of meniscal fibrocartilage, a major mechanical load-bearing tissue of the knee joint, and its functional matrix-forming fibrochondrocytes to mechanical unloading events.

Methods

In this study, primary meniscus fibrochondrocytes isolated from the inner avascular region of human menisci from both male and female donors were seeded into porous collagen scaffolds to generate 3D meniscus models. These models were subjected to both normal gravity and mechanical unloading via simulated micrograv

SUBMITTER: Ma Z 

PROVIDER: S-EPMC11191296 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature