Preliminary research on LncRNA ATP2B2-IT2 in neovascularization of diabetic retinopathy.

ABSTRACT:

Objective

Diabetic retinopathy (DR) is a common complication of diabetes, and recent findings have shown that long noncoding RNAs (lncRNAs) may be involved in its pathogenesis. Through bioinformatics analysis, we found that lncRNA ATP2B2-IT2 may be involved in this process. This study primarily investigated the expression of the lncRNA ATP2B2-IT2 in human retinal microvascular endothelial cells (HRMECs) under high-glucose conditions and its effects on HRMEC proliferation, migration, and neovascularization.

Methods

We used RT‒PCR to assess the expression levels of lncRNA ATP2B2-IT2 and vascular endothelial growth factor (VEGF) in HRMECs under normal glucose (5.5 mmol/L) and high glucose (30 mmol/L) conditions. HRMECs were subsequently divided into four groups: the normal gluc

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC11191339 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature