Genomic and immunocyte characterisation of bloodstream infection caused by Klebsiella pneumoniae.

ABSTRACT:

Objectives

The aim of this study was to evaluate the characteristics of immunocyte associated with bloodstream infection (BSI) caused by Klebsiella pneumoniae (Kpn).

Methods

Patients with BSI-Kpn were included from 2015 to 2022 in our hospital. Immunocyte subpopulations of enrolled BSI-Kpn patients were tested on the same day of blood culture using multicolor flow cytometry analysis. Antibiotic susceptibility test was determined by agar dilution or broth dilution method. All included isolates were subjected to whole genome sequencing and comparative genomics analysis. Clinical and genetic data were integrated to investigate the risk factors associated with clinical outcome.

Results

There were 173 patients with non-duplicate BSI-Kpn, including 81 carbapenem-resistant K

SUBMITTER: Yu W 

PROVIDER: S-EPMC11191348 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature