Reversible Chemical Modification of Antibody Effector Function Mitigates Unwanted Systemic Immune Activation.

ABSTRACT: Antibody effector functions including antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP) are mediated through the interaction of the antibody Fc region with Fcγ receptors present on immune cells. Several approaches have been used to modulate antibody Fc-Fcγ interactions with the goal of driving an effective antitumor immune response, including Fc point mutations and glycan modifications. However, robust antibody-Fcγ engagement and immune cell binding of Fc-enhanced antibodies in the periphery can lead to the unwanted induction of systemic cytokine release and other dose-limiting infusion-related reactions. Creating a balance between effective engagement of Fcγ receptors that can induce antitumor activity without incurring systemic immune activation is an ongoing challe

SUBMITTER: Moquist PN 

PROVIDER: S-EPMC11191404 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature