Mass Spectrometry Proteomics Characterization of Plasma Biomarkers for Colorectal Cancer Associated With Inflammation.

ABSTRACT:

Background

Colorectal cancer (CRC) prognosis is determined by the disease stage with low survival rates for advanced stages. Current CRC screening programs are mainly using colonoscopy, limited by its invasiveness and high cost. Therefore, non-invasive, cost-effective, and accurate alternatives are urgently needed.

Objective and design

This retrospective multi-center plasma proteomics study was performed to identify potential blood-based biomarkers in 36 CRC patients and 26 healthy volunteers by high-resolution mass spectrometry proteomics followed by the validation in an independent CRC cohort (60 CRC patients and 44 healthy subjects) of identified selected biomarkers.

Results

Among the 322 identified plasma proteins, 37 were changed between CRC patients and healthy

SUBMITTER: Urbiola-Salvador V 

PROVIDER: S-EPMC11191626 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature