The association between declining lung function and stroke risk: insights from an observational study and Mendelian randomization.

ABSTRACT:

Background

Stroke, prevalent globally, particularly impacts low- and middle-income countries. Decreased lung function is one of the risk factors for stroke, and there is a lack of sufficient research on the association between the two, especially based on evidence from representative large samples. We aimed to explore the association between lung function and stroke incidence.

Methods

We collected data from 13,371 participants from the 2007-2012 U.S. national cross-sectional study and 11,192 participants from the Chinese national cohort study during the 2011-2018 follow-up period. Multivariate logistic regression and Cox proportional hazards regression were used to assess cross-sectional and longitudinal associations of peak expiratory flow with stroke risks. Additionally, w

SUBMITTER: Wang J 

PROVIDER: S-EPMC11191779 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature