Serum proteomics study on cognitive impairment after cardiac valve replacement surgery: a prospective observational study.

ABSTRACT:

Objective

The incidence of perioperative neurocognitive disorders (PND) is high, especially after cardiac surgeries, and the underlying mechanisms remain elusive. Here, we conducted a prospective observational study to observe serum proteomics differences in PND patients after cardiac valve replacement surgery.

Methods

Two hundred and twenty-six patients who underwent cardiac valve surgery were included. They were categorized based on scoring into non-PND group (group non-P) and PND group (group P'). The risk factors associated with PND were analyzed. These patients were further divided into group C and group P by propensity score matching (PSM) to investigate the serum proteome related to the PND by serum proteomics.

Results

The postoperative 6-week incidence of PND

SUBMITTER: Ma H 

PROVIDER: S-EPMC11192023 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature