Molecular Epidemiology of Clostridioides difficile Colonization in Families With Infants.

ABSTRACT:

Background

Community-associated Clostridioides difficile infection is a major public health hazard to adults and older children. Infants frequently excrete toxigenic C difficile asymptomatically in their stool, but their importance as a community reservoir of C difficile is uncertain.

Methods

Families of healthy infants were recruited at the baby's 4-month well child visit and were followed longitudinally until the baby was approximately 9 months old. Babies and mothers submitted stool or rectal swabs every 2 weeks that were cultivated for C difficile; fathers' participation was encouraged but not required. Clostridioides difficile isolates were strain-typed by fluorescent polymerase chain reaction ribotyping and by core genome multilocus s

SUBMITTER: Marlow C 

PROVIDER: S-EPMC11192056 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature