Causal Associations of Environmental Pollution and Cardiovascular Disease: A Two-Sample Mendelian Randomization Study.

ABSTRACT:

Background

There is growing evidence that concentrations of environmental pollutants are previously associated with cardiovascular disease; however, it is unclear whether this association reflects a causal relationship.

Methods

We utilized a two-sample Mendelian randomization (MR) approach to investigate how environmental pollution affects the likelihood of developing cardiovascular disease. We primarily employed the inverse variance weighted (IVW) method. Additionally, to ensure the robustness of our findings, we conducted several sensitivity analyses using alternative methodologies. These included maximum likelihood, MR-Egger regression, weighted median method and weighted model methods.

Results

Inverse variance weighted estimates suggested that an SD increase in PM

SUBMITTER: Gao H 

PROVIDER: S-EPMC11192098 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature