Multiomics integration-based immunological characterizations of adamantinomatous craniopharyngioma in relation to keratinization.

ABSTRACT: Although adamantinomatous craniopharyngioma (ACP) is a tumour with low histological malignancy, there are very few therapeutic options other than surgery. ACP has high histological complexity, and the unique features of the immunological microenvironment within ACP remain elusive. Further elucidation of the tumour microenvironment is particularly important to expand our knowledge of potential therapeutic targets. Here, we performed integrative analysis of 58,081 nuclei through single-nucleus RNA sequencing and spatial transcriptomics on ACP specimens to characterize the features and intercellular network within the microenvironment. The ACP environment is highly immunosuppressive with low levels of T-cell infiltration/cytotoxicity. Moreover, tumour-associated macrophages (TAMs), which orig

SUBMITTER: Xu C 

PROVIDER: S-EPMC11192745 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature