Magneto-optical assessment of Plasmodium parasite growth via hemozoin crystal size.

ABSTRACT: Hemozoin is a natural biomarker formed during the hemoglobin metabolism of Plasmodium parasites, the causative agents of malaria. The rotating-crystal magneto-optical detection (RMOD) has been developed for its rapid and sensitive detection both in cell cultures and patient samples. In the current article we demonstrate that, besides quantifying the overall concentration of hemozoin produced by the parasites, RMOD can also track the size distribution of the hemozoin crystals. We establish the relations between the magneto-optical signal, the mean parasite age and the median crystal size throughout one erythrocytic cycle of Plasmodium falciparum parasites, where the latter two are determined by optical and scanning electron microscopy, respectively. The significant correlation between the m

SUBMITTER: Orban A 

PROVIDER: S-EPMC11192761 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature