Role of FFAR3 in ketone body regulated glucagon-like peptide 1 secretion.

ABSTRACT:

Background

Roux-en-Y gastric bypass (RYGB) is an effective treatment for obesity, resulting in long-term weight loss and rapid remission of type 2 diabetes mellitus. Improved glucagon-like peptide 1 (GLP-1) levels is one factor that contributes to the positive effects. Prior to RYGB, GLP-1 response is blunted which can be attributed to intestinal ketogenesis. Intestinal produced ketone bodies inhibit GLP-1 secretion in enteroendocrine cells via an unidentified G-protein coupled receptors (GPCRs). A possible class of GPCRs through which ketone bodies may reach are the free fatty acid receptors (FFARs) located at the basolateral membrane of enteroendocrine cells.

Aim

To evaluate FFAR3 expression in enteroendocrine cells of the small intestine under different circumstances, suc

SUBMITTER: Persson SM 

PROVIDER: S-EPMC11192792 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature