A Mendelian randomization study between metabolic syndrome and its components with prostate cancer.

ABSTRACT: Previous research has produced inconsistent findings concerning the connection between metabolic syndrome and prostate cancer. It is challenging for observational studies to establish a conclusive causal relationship between the two. However, Mendelian randomization can provide stronger evidence of causality in this context. To examine the causal link between a metabolic composite and its components with prostate cancer, we performed a two-sample Mendelian randomization (MR) study utilizing aggregated data from genome-wide association studies, followed by meta-analyses. In our study, we employed inverse variance weighting as the primary method for MR analysis. Additionally, we assessed potential sources of heterogeneity and horizontal pleiotropy through the Cochran's Q test and MR-Egger re

SUBMITTER: Xia L 

PROVIDER: S-EPMC11192917 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature