Analysis of 206 whole-genome resequencing reveals selection signatures associated with breed-specific traits in Hu sheep.

ABSTRACT: As an invaluable Chinese sheep germplasm resource, Hu sheep are renowned for their high fertility and beautiful wavy lambskins. Their distinctive characteristics have evolved over time through a combination of artificial and natural selection. Identifying selection signatures in Hu sheep can provide a straightforward insight into the mechanism of selection and further uncover the candidate genes associated with breed-specific traits subject to selection. Here, we conducted whole-genome resequencing on 206 Hu sheep individuals, each with an approximate 6-fold depth of coverage. And then we employed three complementary approaches, including composite likelihood ratio, integrated haplotype homozygosity score and the detection of runs of homozygosity, to detect selection signatures. In total,

SUBMITTER: Zhao F 

PROVIDER: S-EPMC11192971 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature