Survival analysis and life expectancy of pediatric patients with spinal muscular atrophy in Thailand.

ABSTRACT:

Background

Survival data for Thai patients with 5q spinal muscular atrophy (SMA), the leading cause of infant mortality worldwide, are lacking.

Objective

This study aimed to determine the survival rates and life expectancies of pediatric patients with SMA types 1, 2, and 3.

Methods

We conducted a retrospective cohort analysis of genetically confirmed 5q SMA patients aged 0-18 years who were treated between 1999 and 2021 at the pediatric neuromuscular clinic of Siriraj Hospital, Bangkok, Thailand. Mortality data were sourced from the Civil Registration Office.

Results

The study included 113 patients: 37 with SMA type 1, 53 with type 2, and 23 with type 3. Life expectancy varied significantly by SMA type: 2.2 years for type 1, 11 years for type 2, and 16.5 years

SUBMITTER: Sittiyuno P 

PROVIDER: S-EPMC11193008 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature