Vascular endothelial growth factor is an effective biomarker for vascular dementia, not for Alzheimer's disease: A meta-analysis.

ABSTRACT:

Introduction

Vascular pathology is known to contribute to dementia and vascular endothelial growth factor (VEGF) is a well-established biomarker associated with vascular alterations. Nonetheless, research findings on VEGF in Alzheimer's disease (AD) and vascular dementia (VaD) are inconsistent across various studies.

Methods

We conducted a meta-analysis to elucidate relationships between VEGF and AD/VaD.

Results

Twenty-four studies were included. Pooled data showed that both blood and cerebrospinal fluid (CSF) VEGF levels were higher in VaD patients, whereas no significant difference was found between AD patients and healthy controls. However, the correlation between blood VEGF and AD was found among studies with AD pathology verification. And blood VEGF levels were h

SUBMITTER: Xu LZ 

PROVIDER: S-EPMC11193096 | biostudies-literature | 2024 Apr-Jun

REPOSITORIES: biostudies-literature