Discovering genomic islands in unannotated bacterial genomes using sequence embedding.

ABSTRACT:

Motivation

Genomic islands (GEIs) are clusters of genes in bacterial genomes that are typically acquired by horizontal gene transfer. GEIs play a crucial role in the evolution of bacteria by rapidly introducing genetic diversity and thus helping them adapt to changing environments. Specifically of interest to human health, many GEIs contain pathogenicity and antimicrobial resistance genes. Detecting GEIs is, therefore, an important problem in biomedical and environmental research. There have been many previous studies for computationally identifying GEIs. Still, most of these studies rely on detecting anomalies in the unannotated nucleotide sequences or on a fixed set of known features on annotated nucleotide sequences.

Results

Here, we present TreasureIsland, which uses a n

SUBMITTER: Banerjee P 

PROVIDER: S-EPMC11193100 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature