Associations between sarcopenia and circulating branched-chain amino acids: a cross-sectional study over 100,000 participants.

ABSTRACT:

Background

Emerging evidence suggests that alterations in BCAA metabolism may contribute to the pathogenesis of sarcopenia. However, the relationship between branched-chain amino acids (BCAAs) and sarcopenia is incompletely understood, and existing literature presents conflicting results. In this study, we conducted a community-based study involving > 100,000 United Kingdom adults to comprehensively explore the association between BCAAs and sarcopenia, and assess the potential role of muscle mass in mediating the relationship between BCAAs and muscle strength.

Methods

Multivariable linear regression analysis examined the relationship between circulating BCAAs and muscle mass/strength. Logistic regression analysis assessed the impact of circulating BCAAs and quartiles of BCAA

SUBMITTER: Liu H 

PROVIDER: S-EPMC11193178 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature