Temporal and spatial heterogeneity of HER2 status in metastatic colorectal cancer.

ABSTRACT:

Background

HER2-targeted therapies have recently emerged as an option in the management of metastatic colorectal cancer (mCRC) overexpressing HER2. However, data regarding HER2 status in primary CRC and its corresponding liver metastases are limited, potentially influencing clinical decisions. Therefore, the aim of this study was to compare the HER2 status in primary CRC and paired liver metastases.

Methods

Patients with mCRC who were operated from their primary colorectal cancer and their corresponding synchronous or metachronous liver metastases, in the digestive surgery department of Besançon University Hospital, between April 1999 and October 2021, were included. Tissue microarrays were constructed from matched primary CRC and liver metastastic tissue samples. HER2 statu

SUBMITTER: D'Angelo F 

PROVIDER: S-EPMC11193188 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature