Doublecortin-like kinase is required for cnidocyte development in Nematostella vectensis.

ABSTRACT: The complex morphology of neurons requires precise control of their microtubule cytoskeleton. This is achieved by microtubule-associated proteins (MAPs) that regulate the assembly and stability of microtubules, and transport of molecules and vesicles along them. While many of these MAPs function in all cells, some are specifically or predominantly involved in regulating microtubules in neurons. Here we use the sea anemone Nematostella vectensis as a model organism to provide new insights into the early evolution of neural microtubule regulation. As a cnidarian, Nematostella belongs to an outgroup to all bilaterians and thus occupies an informative phylogenetic position for reconstructing the evolution of nervous system development. We identified an ortholog of the microtubule-binding prote

SUBMITTER: Kraus JEM 

PROVIDER: S-EPMC11193195 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature