Trends and off-label utilization of antipsychotics in children and adolescents from 2016 to 2021 in China: a real-world study.

ABSTRACT:

Background

Global antipsychotic usage, including off-label prescriptions, has increased in recent decades. However, trends in China, particularly for children and adolescents, remain unclear. This study explored these trends from 2016 to 2021 and identified factors associated with off-label prescriptions.

Methods

In this retrospective study, we analyzed on-label and off-label prescriptions based on drug information approved by the China National Medical Products Administration. To identify factors associated with off-label prescriptions, we conducted multivariate logistic regression analysis.

Results

Our study included 48,258 antipsychotic prescriptions, 52.4% (25,295) of which were prescriptions for males. Of these, 61.7% (29,813) were off-label. Over time, the numbe

SUBMITTER: Zhaojian W 

PROVIDER: S-EPMC11193198 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature