Methylome analysis in girls with idiopathic central precocious puberty.

ABSTRACT:

Background

Genetic and environmental factors are implicated in many developmental processes. Recent evidence, however, has suggested that epigenetic changes may also influence the onset of puberty or the susceptibility to a wide range of diseases later in life. The present study aims to investigate changes in genomic DNA methylation profiles associated with pubertal onset analyzing human peripheral blood leukocytes from three different groups of subjects: 19 girls with central precocious puberty (CPP), 14 healthy prepubertal girls matched by age and 13 healthy pubertal girls matched by pubertal stage. For this purpose, the comparisons were performed between pre- and pubertal controls to identify changes in normal pubertal transition and CPP versus pre- and pubertal controls.

Res

SUBMITTER: Palumbo S 

PROVIDER: S-EPMC11193236 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature