Dietary factors in relation to hypertension: a mendelian randomization study.

ABSTRACT:

Background

Observational studies have elucidated the associations between dietary factors and hypertension. Nevertheless, the exploration of these relationships using Mendelian randomization remains scarce currently.

Methods

The Mendelian randomization approach investigated the potential causal relationships between 16 dietary factors and hypertension. To achieve this, we identified genetic variants associated with these dietary factors by utilizing data from European-descent genome-wide association studies with a stringent significance threshold (P < 5 × 10 - 8). Subsequently, we obtained genetic associations with hypertension from the extensive FinnGen Study, encompassing 92,462 cases and 265,626 controls. Our primary analytical method was the inverse variance weighted met

SUBMITTER: Cai J 

PROVIDER: S-EPMC11193250 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature