Deregulated immune cell recruitment orchestrated by c-MET impairs pulmonary inflammation and fibrosis.

ABSTRACT:

Background

Pulmonary fibrosis (PF) represents the pathologic end stage of several interstitial lung diseases (ILDs) associated with high morbidity and mortality rates. However, current treatments can only delay disease progression rather than provide a cure. The role of inflammation in PF progression is well-established, but new insights into immune regulation are fundamental for developing more efficient therapies. c-MET signaling has been implicated in the migratory capacity and effector functions of immune cells. Nevertheless, the role of this signaling pathway in the context of PF-associated lung diseases remains unexplored.

Methods

To determine the influence of c-MET in immune cells in the progression of pulmonary fibrosis, we used a conditional deletion of c-Met in imm

SUBMITTER: Barbosa-Matos C 

PROVIDER: S-EPMC11193258 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature