Identification of lipid-modifying drug targets for autoimmune diseases: insights from drug target mendelian randomization.

ABSTRACT:

Backgrounds

A growing body of evidence has highlighted the interactions of lipids metabolism and immune regulation. Nevertheless, there is still a lack of evidence regarding the causality between lipids and autoimmune diseases (ADs), as well as their possibility as drug targets for ADs.

Objectives

This study was conducted to comprehensively understand the casual associations between lipid traits and ADs, and evaluate the therapeutic possibility of lipid-lowering drug targets on ADs.

Methods

Genetic variants for lipid traits and variants encoding targets of various lipid-lowering drugs were derived from Global Lipid Genetics Consortium (GLGC) and verified in Drug Bank. Summary data of ADs were obtained from MRC Integrative Epidemiology Unit (MER-IEU) database and FinnG

SUBMITTER: Hu X 

PROVIDER: S-EPMC11193261 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature