The impact of antifibrotic use on long-term clinical outcomes in the pulmonary fibrosis foundation registry.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease (ILD) with a high mortality rate. The antifibrotic medications pirfenidone and nintedanib have been in use since 2014 for this disorder and are associated with improved rate of lung function decline. Less is known about their long-term outcomes outside of the clinical trial context.

Methods

The Pulmonary Fibrosis Foundation Patient Registry was used for this study. Patients with an IPF diagnosis made within a year of enrollment were included. The treated group was defined as patients receiving either pirfenidone or nintedanib for at least 180 days. The untreated group did not have any record of antifibrotic use. Demographic data, comorbidities, serial lung function, hospitalization, and

SUBMITTER: Lee CT 

PROVIDER: S-EPMC11193272 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature