Epidemiological and genomic characteristics of global blaNDM-carrying Escherichia coli.

ABSTRACT:

Background

Escherichia. coli is the most frequent host for New Delhi metallo-β-lactamase (NDM) which hydrolyzes almost all β-lactams except aztreonam. The worldwide spread of blaNDM-carrying E. coli heavily threatens public health.

Objective

This study aimed to explore the global genomic epidemiology of blaNDM- carrying E. coli isolates, providing information for preventing the dissemination of such strains.

Methods

Global E. coli genomes were downloaded from NCBI database and blaNDM was detected using BLASTP. Per software was used to extract meta information on hosts, resources, collection data, and countries of origin from GenBank. The sequence types (STs) and distribution of antimicrobial resistance gene (ARG) were analyzed by CLC Workbench; Plasmid replicons, sero

SUBMITTER: Xia C 

PROVIDER: S-EPMC11193274 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature