Family history and gastric cancer incidence and mortality in Asia: a pooled analysis of more than half a million participants.

ABSTRACT:

Background

The family history of gastric cancer holds important implications for cancer surveillance and prevention, yet existing evidence predominantly comes from case-control studies. We aimed to investigate the association between family history of gastric cancer and gastric cancer risk overall and by various subtypes in Asians in a prospective study.

Methods

We included 12 prospective cohorts with 550,508 participants in the Asia Cohort Consortium. Cox proportional hazard regression was used to estimate study-specific adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between family history of gastric cancer and gastric cancer incidence and mortality, then pooled using random-effects meta-analyses. Stratified analyses were performed for t

SUBMITTER: Huang D 

PROVIDER: S-EPMC11193690 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature