Pharmacological Modulation of the Cytosolic Oscillator Affects Glioblastoma Cell Biology.

ABSTRACT: The circadian system is a conserved time-keeping machinery that regulates a wide range of processes such as sleep/wake, feeding/fasting, and activity/rest cycles to coordinate behavior and physiology. Circadian disruption can be a contributing factor in the development of metabolic diseases, inflammatory disorders, and higher risk of cancer. Glioblastoma (GBM) is a highly aggressive grade 4 brain tumor that is resistant to conventional therapies and has a poor prognosis after diagnosis, with a median survival of only 12-15 months. GBM cells kept in culture were shown to contain a functional circadian oscillator. In seeking more efficient therapies with lower side effects, we evaluated the pharmacological modulation of the circadian clock by targeting the cytosolic kinases glycogen synthase

SUBMITTER: Wagner PM 

PROVIDER: S-EPMC11193694 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature