Interactomic exploration of LRRC8A in volume-regulated anion channels.

ABSTRACT: Ion channels are critical in enabling ion movement into and within cells and are important targets for pharmacological interventions in different human diseases. In addition to their ion transport abilities, ion channels interact with signalling and scaffolding proteins, which affects their function, cellular positioning, and links to intracellular signalling pathways. The study of "channelosomes" within cells has the potential to uncover their involvement in human diseases, although this field of research is still emerging. LRRC8A is the gene that encodes a crucial protein involved in the formation of volume-regulated anion channels (VRACs). Some studies suggest that LRRC8A could be a valuable prognostic tool in different types of cancer, serving as a biomarker for predicting patients' ou

SUBMITTER: Carpanese V 

PROVIDER: S-EPMC11193767 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature