Observational study of frailty in older Japanese patients with non-valvular atrial fibrillation receiving anticoagulation therapy.

ABSTRACT: The number of patients with atrial fibrillation is increasing, and frailty prevalence increases with age, posing challenges for physicians in prescribing anticoagulants to such patients because of possible harm. The effects of frailty on anticoagulant therapy in older Japanese patients with nonvalvular atrial fibrillation (NVAF) are unclear. Herein, we prescribed rivaroxaban to Japanese patients with NVAF and monitored for a mean of 2.0 years. The primary endpoint was stroke or systemic embolism. The secondary endpoints were all-cause or cardiovascular death, composite endpoint, and major or non-major bleeding. Frailty was assessed using the Japanese long-term care insurance system. A multiple imputation technique was used for missing data. The propensity score (PS) was obtained to estimat

SUBMITTER: Matsui K 

PROVIDER: S-EPMC11193807 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature