Neural Correlates of Irritability in Disruptive Mood Dysregulation and Bipolar Disorders.

ABSTRACT:

Objective

Bipolar disorder and disruptive mood dysregulation disorder (DMDD) are clinically and pathophysiologically distinct, yet irritability can be a clinical feature of both illnesses. The authors examine whether the neural mechanisms mediating irritability differ between bipolar disorder and DMDD, using a face emotion labeling paradigm because such labeling is deficient in both patient groups. The authors hypothesized that during face emotion labeling, irritability would be associated with dysfunctional activation in the amygdala and other temporal and prefrontal regions in both disorders, but that the nature of these associations would differ between DMDD and bipolar disorder.

Method

During functional MRI acquisition, 71 youths (25 with DMDD, 24 with bipolar disorder,

SUBMITTER: Wiggins JL 

PROVIDER: S-EPMC11193882 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature