The RNA secondary structure of androgen receptor-FL and V7 transcripts reveals novel regulatory regions.

ABSTRACT: The androgen receptor (AR) is a ligand-dependent nuclear transcription factor belonging to the steroid hormone nuclear receptor family. Due to its roles in regulating cell proliferation and differentiation, AR is tightly regulated to maintain proper levels of itself and the many genes it controls. AR dysregulation is a driver of many human diseases including prostate cancer. Though this dysregulation often occurs at the RNA level, there are many unknowns surrounding post-transcriptional regulation of AR mRNA, particularly the role that RNA secondary structure plays. Thus, a comprehensive analysis of AR transcript secondary structure is needed. We address this through the computational and experimental analyses of two key isoforms, full length (AR-FL) and truncated (AR-V7). Here, a combinat

SUBMITTER: Rouse WB 

PROVIDER: S-EPMC11194067 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature