AsteRIa enables robust interaction modeling between chromatin modifications and epigenetic readers.

ABSTRACT: Chromatin, the nucleoprotein complex consisting of DNA and histone proteins, plays a crucial role in regulating gene expression by controlling access to DNA. Chromatin modifications are key players in this regulation, as they help to orchestrate DNA transcription, replication, and repair. These modifications recruit epigenetic 'reader' proteins, which mediate downstream events. Most modifications occur in distinctive combinations within a nucleosome, suggesting that epigenetic information can be encoded in combinatorial chromatin modifications. A detailed understanding of how multiple modifications cooperate in recruiting such proteins has, however, remained largely elusive. Here, we integrate nucleosome affinity purification data with high-throughput quantitative proteomics and hierarchic

SUBMITTER: Stadler M 

PROVIDER: S-EPMC11194111 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature