Expansion of effector memory Vδ2^neg γδ T cells associates with cytomegalovirus reactivation in allogeneic stem cell transplant recipients.

ABSTRACT:

Background

Cytomegalovirus (CMV) reactivation is a significant concern following allogeneic stem cell transplantation. While previous research has highlighted the anti-CMV reactivation effect of γδ T cells in immunocompromised transplant patients, their characterization in recipients at high risk of CMV reactivation remains limited.

Methods

This study focused on D+/R+ recipients (where both donor and recipient are CMV seropositive) at high risk of CMV reactivation. We analyzed 28 patients who experienced CMV recurrence within 100 days post-allogeneic hematopoietic stem cell transplantation, along with 36 matched recipients who did not experience CMV recurrence. Clinical data from both groups were compared, and risk factors for CMV reactivation were identified. Additionally,

SUBMITTER: Huang Y 

PROVIDER: S-EPMC11194311 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature