Albumin and multiple sclerosis: a prospective study from UK Biobank.

ABSTRACT:

Background

Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system. While previous studies have indicated that albumin, the primary protein in human plasma, may exert influence on the inflammatory process and confer beneficial effects in neurodegenerative disorders, its role in the context of MS has been underexplored. Here, we aimed to explore the link between albumin and the risk of MS.

Methods

Employing data from the UK Biobank, we investigated the association between baseline levels of serum and urine albumin and the risk of MS using Cox proportional hazards regression analysis.

Results

A higher baseline level of serum albumin was associated with a lower risk of incident MS (HR=0.94, 95% CI: 0.91-0.98, P=7.66E-04). Subgroup a

SUBMITTER: Chen K 

PROVIDER: S-EPMC11194376 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature